References

_{1. Smith CB. Holland-Frei Cancer Medicine. John Wiley & Sons, 2017, Ch 46, p523. 
2. Dueñas M et al. A review of chronic pain impact on patients, their social environment and the health care system. Journal of Pain Research, 28 June 2016, p457. 
3. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds. Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p267. 
4. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds. Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p268. 
5. Dubin AE, Patapoutian A. Nociceptors: the sensors of the pain pathway. The Journal of Clinical Investigation, Volume 120, Number 11, November 2010, p3761.
6. National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations. Pain: Current Understanding of Assessment, Management, and Treatments. Reston, VA: National Pharmaceutical Council; 2001. 
7. American Chronic Pain Association. https://www.theacpa.org/conditions-treatments/conditions-a-z/neuropathic-pain/. Accessed 2020-02-14 at 4.41.19 PM. 
8. National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations. Pain: Current Understanding of Assessment, Management, and Treatments. Reston, VA: National Pharmaceutical Council; 2001. 
9. Smith CB. Holland-Frei Cancer Medicine. John Wiley & Sons, 2017, Ch 46, p523. 
10. Vasko M.R. (2009) Inflammatory Pain. In: Binder M.D., Hirokawa N., Windhorst U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://link.springer.com/referenceworkentry/10.1007%2F978-3-540-29678-22436. Accessed Feb 14, 2020. 
11. Vasko M.R. (2009) Inflammatory Pain. In: Binder M.D., Hirokawa N., Windhorst U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://link.springer.com/referenceworkentry/10.1007%2F978-3-540-29678-22436. Accessed Feb 14, 2020. 
12. Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014 Feb 5; 348:f7656, p3.  
13. Shah JP. Myofascial Trigger Points, Sensitization and the Unique Neurobiology of Muscle Pain. Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health. 2010. p2. 
14. Shah JP. Myofascial Trigger Points, Sensitization and the Unique Neurobiology of Muscle Pain. Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health. 2010. p3. 
15. Shah JP. Myofascial Trigger Points, Sensitization and the Unique Neurobiology of Muscle Pain. Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health. 2010. 
16. Maloney RD et al. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Frontiers in Psychiatry. February 2015, Vol 6, Article 15, p1. 
17. Smith CB. Holland-Frei Cancer Medicine. John Wiley & Sons, 2017, Ch 46, p523 
18. Maloney RD et al. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Frontiers in Psychiatry. February 2015, Vol 6, Article 15, p1. 
19. Urden LD et al. Priorities in Critical Care Nursing. Eighth edition. Evolve. 2019. p57. 
20. Maloney RD et al. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Frontiers in Psychiatry. February 2015, Vol 6, Article 15, p1. 
21. Maloney RD et al. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Frontiers in Psychiatry. February 2015, Vol 6, Article 15, p2. 
22. Smith CB. Holland-Frei Cancer Medicine. John Wiley & Sons, 2017, Ch 46, p523. 
23. Maloney RD et al. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Frontiers in Psychiatry. February 2015, Vol 6, Article 15, p1. 
24. Cervero F. Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol. Rev 1994. 74, p97, 99. 
25. Cervero F. Visceral versus Somatic Pain: Similarities and Differences. Digestive Diseases. 2009, p4. 
26. Cervero F. Visceral versus Somatic Pain: Similarities and Differences. Digestive Diseases. 2009, p6. 
27. Smith CB. Holland-Frei Cancer Medicine. John Wiley & Sons, 2017, Ch 46, p523. 
28. Murray GM. Guest Editorial: referred pain. J Appl Oral Sci. 2009;17(6). p1. 
29. Kulkami R. Clincal Evaluation of Upper and Mid-Back Pain. Journal on Recent Advances in Pain. Sep-Dec 2015, p88. 
30. International Association for the Study of Pain (IASP). Classification of Chronic Pain, 2nd Edition (Revised). Seattle, WA: IASP Press; 2012. p7.    
31. Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014 Feb 5; 348:f7656, p4. 
32. International Association for the Study of Pain (IASP). Classification of Chronic Pain, 2nd Edition (Revised). Seattle, WA: IASP Press; 2012. P8.    
33. Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014 Feb 5; 348:f7656, p4. 
34. Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014 Feb 5; 348:f7656, p4. 
35. International Association for the Study of Pain (IASP). Classification of Chronic Pain, 2nd Edition (Revised). Seattle, WA: IASP Press; 2012. p7. 
36. National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations. Pain: Current Understanding of Assessment, Management, and Treatments. Reston, VA: National Pharmaceutical Council; 2001. p4. 
37. Mersky H, Bogduk N. Part III: Pain Terms, A Current List with Definitions and Notes on Usage. IASP Task Force on Taxonomy. 2017. p8. 
38. National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations. Pain: Current Understanding of Assessment, Management, and Treatments. Reston, VA: National Pharmaceutical Council; 2001. p10. 
39. Ossipov MH. The Perception and Endogenous Modulation of Pain. Scientifica. 2012. p1-2. 
40. National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations. Pain: Current Understanding of Assessment, Management, and Treatments. Reston, VA: National Pharmaceutical Council; 2001. p4. 
41. National Pharmaceutical Council and Joint Commission on Accreditation of Healthcare Organizations. Pain: Current Understanding of Assessment, Management, and Treatments. Reston, VA: National Pharmaceutical Council; 2001. P6. 
42. Buschmann H et al. Analgesics. Wiley-VCH. 2002. p5. 
43. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds.Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p277. 
44. Tobaldini G. Pain Inhibits Pain: an Ascending-Descending Pain Modulation Pathway Linking Mesolimbic and Classical Descending Mechanisms. Molecular Neurobiology. 2019. p1-2. 
45. Wall and Melzack’s Textbook of Pain, 5th Edition. 2006. p130-135. 
46. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds. Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p281. 
47. NPC and JCAHO. Pain: Current Understanding of Assessment, Management, and Treatments. 2001. p7. 
48. Dunteman ED. Mechanisms and treatment issues for neuropathic pain. CAN J ANESTH. 2004. pR2. 
49. Dunteman ED, CAN J ANESTH 2004 / 51: 6 / pR1. 
50. Dunteman ED, CAN J ANESTH 2004 / 51: 6 / pR1. 
51. Ahlawat A. Comprehensive review on molecular mechanisms of neuropathic pain. Journal of Innovations in Pharmaceutical and Biological Sciences. 2017. p1. 
52. Meacham K et al. Neuropathic Pain: Central vs. Peripheral Mechanisms. Curr Pain Headache Rep. 2017. p28. 
53. Zhou XL et al. Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. Molecular Pain 2014. p1-2. 
54. Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014 Feb 5; 348:f7656, p4. 
55. Meacham K et al. Neuropathic Pain: Central vs. Peripheral Mechanisms. Curr Pain Headache Rep. 2017. p28.
56. Meacham K et al. Neuropathic Pain: Central vs. Peripheral Mechanisms. Curr Pain Headache Rep. 2017. p27-28.
57. Truini A et al. Reappraising neuropathic pain in humans-how symptoms help disclose mechanisms. Nat. Rev. Neurol. 9, 572-582. 2013. p575. 
58. Alves JM, Lin K. Neuropathic Pain: A Review of Interneuronal Disinhibition. Arch Neurosci. 2018. p1,3. 
59. Moore KA et al. Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition. Journal of Neuroscience. 2002. p6730. 
60. Zhou XL et al. Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. Molecular Pain 2014. p1-2. 
61. Wall & Melzack. Textbook of Pain, 5th Edition. 2006. p16.  
62. Ossipov MH. The Perception and Endogenous Modulation of Pain.2012. p6. 
63. Wall & Melzack.Textbook of Pain, 5th Edition. 2006. p16. 
64. Wall & Melzack. Textbook of Pain, 5th Edition. 2006. p36. 
65. Wall & Melzack Textbook of Pain, 5th Edition. 2006. p36. 
66. Wall & Melzack. Textbook of Pain, 5th Edition. p36. 
67. Wall & Melzack. Textbook of Pain, 5th Edition. p51. 
68. Wall & Melzack. Textbook of Pain, 5th Edition. p17. 
69. Mizumura K, Murase S. Role of Nerve Growth Factor in Pain. In: Schaible HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer. 2015. p58.  
70. Mizumura K, Murase S. Role of Nerve Growth Factor in Pain. In: Schaible HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer. 2015. p59.  
71. Mizumura K, Murase S. Role of Nerve Growth Factor in Pain. In: Schaible HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer. 2015. p64.  
72. Mizumura K, Murase S. Role of Nerve Growth Factor in Pain. In: Schaible HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer. 2015. p66.  
73. Mizumura K, Murase S. Role of Nerve Growth Factor in Pain. In: Schaible HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer. 2015. p66.  
74. Stratiievska A et al. Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor. Elife. Dec 2018. p1.   
75. Stratiievska A et al. Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor. Elife. Dec 2018. p2.   
76. Jay P. Shah, MD, Elizabeth A. Gilliams, BA. Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: An application of muscle pain concepts to myofascial pain syndrome. Bodywork and Journal of Movement Therapies, June 2008, p375. 
77. Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede RD. Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain. 2002 Mar;96(1-2), p142. 
78. Hartmann B et al. The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain. Neuron, Vol. 44, 637–650, November 18, 2004, p643. 
79. Chapman CR et al.  Pain and Stress in a Systems Perspective. J Pain. 2008 February; 9(2): p21. 
80. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds. Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p276. 
81. Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede RD. Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain. 2002 Mar;96(1-2), p150. 
82. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds. Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p267. 
83. Apkarian AV. Pain perception in relation to emotional learning. Curr Opin Neurobiol. 2008. p464. 84. Sandkühler J. Learning and memory in pain pathways. Pain 88. 2000. p113. 
85. Sandkühler J. Learning and memory in pain pathways. Pain 88. 2000. p114. 
86. Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005. p463. 
87. Tracey I, Manty PW. The Cerebral Signature for Pain Perception and Its Modulation. Neuron, Volume 55, Issue 3, 377-391, 2 August 2007. p378, 382. 
88. Tracey I, Manty PW. The Cerebral Signature for Pain Perception and Its Modulation. Neuron, Volume 55. 2007. p382. 
89. Tracey I, Manty PW. The Cerebral Signature for Pain Perception and Its Modulation. Neuron, Volume 55, Issue 3, 377-391, 2 August 2007. 383. 
90. Purves D et al. The Physiological Basis of Pain Modulation – Neuroscience, 2nd edition. 2001. p1. 
91. Kirkpatrick DR et al. Therapeutic Basis of Clinical Pain Modulation. CTS vol 8, issue 6, 11 May 2015, p848. 
92. Mendell LM. Constructing and Deconstructing the Gate Theory of Pain. Pain. 2014. p6 
93. Porreca F, Ossipov M H, Gebhart G F 2002 Chronic pain and medullary descending facilitation. Trends in Neurosciences. p319. 
94. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds. Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p281. 
95. Porreca F, Ossipov M H, Gebhart G F 2002 Chronic pain and medullary descending facilitation. Trends in Neurosciences. p319. 
96. Fields HL, Basbaum AI, Heinricher MM. Central nervous system mechanisms of pain modulation. Wall & Melzack’s Textbook of Pain, 5th edition, p130. 
97. Hudspith MJ, Siddall PJ, Munglani R. Physiology of pain. In: Hemming HC, Hopkins PM, eds.Foundations of Anesthesia. 2nd ed. London, UK: Mosby; 2006. p281. 
98. Fields HL, Basbaum AI, Heinricher MM. Central nervous system mechanisms of pain modulation. Wall & Melzack’s Textbook of Pain, 5th edition, P 128. 
99. Dafeny N. Pain Modulation and Mechanisms Section 2, Chapter 8 Neuroscience Online. U of Texas. 1997. p3. 
100. Fields HL, Basbaum AI, Heinricher MM. Central nervous system mechanisms of pain modulation. Wall & Melzack’s Textbook of Pain, 5th edition, p125.   
101. Chapman C, Tuckett R, Song C. Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions. The Journal of Pain, 2008, Volume 9, Issue 2, Pages 122-145 (PDF p1). 
102. Jänig W, Levine JD. Autonomic-endocrine-immune interactions in acute and chronic pain. Wall and Melzack, Textbook of Pain, Chap 12, p206 (PDF p1). 
103. Chapman C, Tuckett R, Song C. Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions. The Journal of Pain, 2008, Volume 9, Issue 2, Pages 122-145 (PDF p21). 
104. Chapman C, Tuckett R, Song C. Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions. The Journal of Pain, 2008, Volume 9, Issue 2, Pages 122-145 (PDF p2,10). 
105. O’Connor TM, O’Halloran DJ, Shanahan F. The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia. Oxford Journal of Medicine, June 2000, Vol. 93:6, p323-333 (PDF p3) 
106. O’Connor TM, O’Halloran DJ, Shanahan F. The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia. Oxford Journal of Medicine, June 2000, Vol. 93:6, p323-333 (PDF p3) 
107. Chapman C, Tuckett R, Song C. Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions. The Journal of Pain, 2008, Volume 9, Issue 2, Pages 122-145 (PDF p15). 
108. Schafer M. Cytokines and peripheral analgesia. Adv Exp Med Biol. 2003. p41. 
109. Chapman C, Tuckett R, Song C. Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions. The Journal of Pain, 2008, Volume 9, Issue 2, Pages 122-145 (PDF p21). 
110. Chapman C, Tuckett R, Song C. Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions. The Journal of Pain, 2008, Volume 9, Issue 2, Pages 122-145 (PDF p21). 
111. Kirkpatrick DR et al. Therapeutic Basis of Clinical Pain Modulation. CTS vol 8, issue 6, 11 May 2015, p849. 
112. Francois A et al. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron 93, 822–839, February 22, 2017, p 822. 
113. Blobaum AL, Marnett LJ. Structural and Functional Basis of Cyclooxygenase Inhibition. Journal of Medicinal Chemistry, 2007, p1425. 
114. Blobaum AL, Marnett LJ. Structural and Functional Basis of Cyclooxygenase Inhibition. Journal of Medicinal Chemistry, 2007, p1425-1426. 
115. Blobaum AL, Marnett LJ. Structural and Functional Basis of Cyclooxygenase Inhibition. Journal of Medicinal Chemistry, 2007, p1427. 
116. Hunter TS et al. Emerging Evidence in NSAID Pharmacology: Important Considerations for Product Selection. AJMC. 2015. P139-140. 
117. Blobaum AL, Marnett LJ. Structural and Functional Basis of Cyclooxygenase Inhibition. Journal of Medicinal Chemistry, 2007, p1427. 
118. Blobaum AL, Marnett LJ. Structural and Functional Basis of Cyclooxygenase Inhibition. Journal of Medicinal Chemistry, 2007, p1428-1429. 
119. Ghanem C. Acetaminophen; From Liver to Brain: New Insights Into Drug Pharmacological Action and Toxicity Pharmacol Res. 2016 July ; 109: p2.   
120. Hunter TS et al. Emerging Evidence in NSAID Pharmacology: Important Considerations for Product Selection. AJMC. 2015. p143. 
121. Jessell TM, Kelly DD. Pain and analgesia. Principles of Neural Science, Third Edition, Kandel et al. editors, 1991, p.397. 
122. Jessell TM, Kelly DD. Pain and analgesia. Principles of Neural Science, Third Edition, Kandel et al. editors, 1991, p.397. 
123. Jessell TM, Kelly DD. Pain and analgesia. Principles of Neural Science, Third Edition, Kandel et al. editors, 1991, p.397. 
124. Ballantyne JC, Fishman SM, Rathmell JP. Bonica’s Management of Pain, 2009, p1173. 
125. Burt, AM. “Histology and Fine Structure of Nervous Tissue,” “Neuronal Communication,” and “Chemical Transmission.” In Textbook of Neuroanatomy. Philadelphia, PA: W. B. Saunders, Co., 1993. 
126. NPC and JCAHO. Pain: Current Understanding of Assessment, Management, and Treatments. 2001 p17. 
127. Katz NP et al. Challenges in the Development of Prescription Opioid Abuse-deterrent FormulationClin J Pain, Volume 23, Number 8, October 2007, p650. 
128. Galinkin J, Koh JL. Recognition and management of iatrogenically induced opioid dependence and withdrawal in children. Pediatrics. 2014. p1. 
129. Katz NP et al. Challenges in the Development of Prescription Opioid Abuse-deterrent FormulationClin J Pain, Volume 23, Number 8, October 2007, p650. 
130. Surgeon General. Facing addiction in America. U.S. Department of Health & Human Services2016. p64-65. 
131. Surgeon General. Facing addiction in America. U.S. Department of Health & Human Services2016. p64-65. 
132. Surgeon General. Facing addiction in America. U.S. Department of Health & Human Services2016. p64-65. 
133. Surgeon General. Facing addiction in America. U.S. Department of Health & Human Services2016. p71. 
134. Hunt SP, Urch CE. Pain, opiates and addiction. Wall and Melzack, Textbook of Pain, 5^th Edition, p.351. 
135. Kalivas PW, Volkow ND. “The neural basis of addiction: a pathology of motivation and choice”. Am J Psychiatry 162 (8) 2005. 1403. 
136. Fulton BS. Physiological Basis of Addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies. 2014. p1. 
137. Fulton BS. Physiological Basis of Addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies. 2014. p2. 
138. Fulton BS. Physiological Basis of Addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies. 2014. p2. 
139. Fulton BS. Physiological Basis of Addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies. 2014. p2. 
140. Fulton BS. Physiological Basis of Addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies. 2014. p3. 
141. Fulton BS. Physiological Basis of Addiction. Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies. 2014. p4.}